Macrophage migration inhibitory factor in obese and non obese women with polycystic ovary syndrome.

نویسندگان

  • Jorly Mejia-Montilla
  • Melchor Álvarez-Mon
  • Eduardo Reyna-Villasmil
  • Duly Torres-Cepeda
  • Joel Santos-Bolívar
  • Nadia Reyna-Villasmil
  • Ismael Suarez-Torres
  • Alfonso Bravo-Henríquez
چکیده

OBJECTIVE To measure macrophage migration inhibitory factor (MIF) concentrations in obese and non-obese women diagnosed with polycystic ovary syndrome (PCOS). METHODS Women diagnosed with PCOS and age-matched healthy controls with regular menses and normal ovaries on ultrasound examination were selected and divided into 4 groups (group A, PCOS and obese; group B, PCOS and non-obese; group C, obese controls; and group D, non-obese controls) based on body mass index (obese >30 kg/m2 and non-obese <25 kg/m2). Luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, sex hormone-binding globulin, serum glucose, insulin and MIF levels were measured. RESULTS Obese and non-obese women with PCOS had higher luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, and insulin levels as compared to the obese and non-obese control groups, respectively (P < .0001). Women with PCOS had significantly higher MIF levels (group A, 48.6 ± 9.9 mg/ml; group B, 35.2 ± 6.0 ng/ml) as compared to controls (group C, 13.5 ± 6.0 ng/ml; group D, 12.0 ± 4.3 ng/dl; P < .0001). A weak, positive and significant correlation was seen between fasting blood glucose and insulin levels in women with PCOS (P < .05). CONCLUSION Significant differences exist in plasma MIF levels between obese and non-obese women with and without PCOS.

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عنوان ژورنال:
  • Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion

دوره 62 1  شماره 

صفحات  -

تاریخ انتشار 2015